Frontiers in Chemical Research
Volume:1 Issue: 1, Summer and Autumn 2019

The optimal protection efficiency of expired Oxazepam product for carbon steel in the 5 % NaCl solution was successfully achieved through weight loss (mass loss), gasometric, colorimetry, atomic absorption spectroscopy (AAS) and scanning electron microscopy (SEM) techniques. The results showed that, the inhibitory behavior of expired Oxazepam drug enhances with a rise in the expired product amounts (four different concentrations), but this property (corrosion inhibition property of expired Oxazepam drug) is inversely related to the contact time (2, 4, 6, 8 and 10 h). Gasometric results exhibited that, disintegration process reduced in the presence of corrosion inhibitor (expired Oxazepam drug) compared to the bare system (unprotected solution). Both atomic absorption spectroscopy and colorimetric studies revealed that, expired Oxazepam drug possesses the indices of robust corrosion inhibitor on the surface of aluminum in the 5 % NaCl solution. The surface study was screened by scanning electron microscopy (SEM) technique and discussed.

Morpholine is a six-membered aromatic organic heterocycle that possesses one nitrogen atom and one oxygen atom their ring structure. Morpholine ring is present in various organic compounds those were developed by chemical designing for diverse pharmacologically activities. In recent years, scientists have explored this moiety. This review summarizes the broad spectrum of pharmacological profile of morpholine derivatives. Six-membered heterocyclic compounds containing oxygen like 2H-pyran and 4H-pyrans constitute an important class of biologically active compounds, playing an essential role in biochemistry and continuing to attract interest. Pyrans and its analogues engage prime position due to their diverse applications. In this review, up to date information about the developments and exploration of methodologies of morpholine and pyran analogues were discussed. This review shows current tendency in the morpholine and pyran analogues and reveals their potent pharmacophoric activities. This article will support to the researcher in future to design and synthesized novel morpholine and pyran derivatives.

A metal-free and iodine promoted oxidative system for cyclization of primary benzyl amines with anthranilamide to afford 2-arylquinazolin-4(3H)-ones in PEG-400 as a green, inexpensive, non-toxic and reusable solvent medium has been developed.

Malaria is a serious human health threat that affects the lives of millions of people annually. To this end, the Quantitative structure–activity relationship (QSAR) of 31 thiazolidinedione derivatives were used to predict anti-malarial activity. Multiple linear regression (MLR) model and artificial neural network (ANN) are used for modeling. The best results were obtained for thiazolidinedione derivatives with 5 descriptors. The obtained results indicated that the MLR implemented for thiazolidinedione derivatives with parameters: R2: 0.90, R2adj: 0.88, Q2: 0.89, and RMSE: 2.06. Also, the ANN was used in which the correlation coefficients of the three groups of train, validation, test and total were 0.94, 0.98, 0.99, and 0.95, respectively. Based on the results, a comparison of the quality of the models show that the ANN model has a significantly better predictive capability. ANN establishes a satisfactory relationship between the molecular descriptors and the activity of the studied compounds.

Celestine blue (CB) was pre-concentrated by dispersive liquid–liquid microextraction (DLLME) and subsequently quantified with spectrophotometry in water samples and simultaneously correlation among response to variables like pH, disperser volume, extractor volume, ionic strong and extraction time was investigated by central composite design (CCD). The numerical optimization indicates that the optimum %ER (100.2%) achieved using 100µL of CHCl3, 800µL of ethanol, 0 mol L-1 NaCl, 5 min centrifugation and pH of 7. At optimal conditions method has linear dynamic range over 0.01-3.0 µg mL-1 with a pre-concentration and enrichment factor of 100 and 147.9, respectively. The limits of detection and quantification were 1.58 and 5.30 ng mL-1, respectively. Average recoveries for spiked samples in the interval of 92% and 100% which supply present DLLME method for CB determination in different waters and wastewaters samples, accordingly at prespecified optimum conditions. Abstract Celestine blue (CB) was pre-concentrated by dispersive liquid–liquid microextraction (DLLME) and subsequently quantified with spectrophotometry in water samples and simultaneously correlation among response to variables like pH, disperser volume, extractor volume, ionic strong and extraction time was investigated by central composite design (CCD). The numerical optimization indicates that the optimum %ER (100.2%) achieved using 100µL of CHCl3, 800µL of ethanol, 0 mol L-1 NaCl, 5 min centrifugation and pH of 7. At optimal conditions method has linear dynamic range over 0.01-3.0 µg mL-1 with a pre-concentration and enrichment factor of 100 and 147.9, respectively. The limits of detection and quantification were 1.58 and 5.30 ng mL-1, respectively. Average recoveries for spiked samples in the interval of 92% and 100% which supply present DLLME method for CB determination in different waters and wastewaters samples, accordingly at prespecified optimum conditions.

Biotransformation of antidepressant drugs is said to affect their pharmacological profile and subsequently alter their treatment efficacies. Imipramine and amitriptyline are the major drugs used for the management of manic depression at the Ankaful psychiatric hospital in Ghana. Recent reports have shown that some patients stay longer on this therapy than expected, while others do not get well at all. Herein, we report a modified solid phase extraction (SPE) method for the extraction of these antidepressant drugs; imipramine, amitriptyline and their respective metabolites, desipramine and 10-hydroxyamitriptyline from urine samples of five adult manic depressed patients. The compounds were simultaneously analyzed by gas chromatography-mass spectrometry (GC-MS). The calibration curves were linear over a range of 10-100 µg/L for all the analytes with the square of the regression coefficient (R2) ranging from 0.990 to 0.997. Analyses of the drugs and their respective metabolites over a 40 day period gave an average of 3.65 µg/L 10-hydroxyamitriptyline with negligible levels of amitriptyline. An average of 27.01 µg/L desipramine was also recorded against 10.30 µg/L of imipramine. These high levels of metabolites and relatively low amounts of the parent drugs recorded in the urine samples could be the main cause of the patients staying longer on the therapy and the resultant abscondment of one of them.